Desarrollo de una aplicación para la gestión integral y el control de una célula de fabricación flexible

El presente documento describe los aspectos funtamentales relacionados con el software de control FMC v1.0. Esta herramienta informática permite controlar eficientemente la Célula de Fabricación Flexible del Laboratorio de Organizacion Industrial y Producción de la Escuela de Ingenierías Industriales de la Universidad de Valladolid. Es capaz de coordinar todos los elementos de la célula, reaccionar ante los imprevistos en el cambio de diseño del producto, averías,..., llevar un control del material en bruto y del que se encuentra en curso de fabricación, etc. Si bien se trata de una aplicación particularizada para unas variables, productos, ... concretos, supone un paso para la creación de nuevos paquetes de software que permitan a muchas empresas mejorar su sistema de información y producción mediante un acercamiento a CIM y a la fabricación flexible.Departamento de Organización de Empresas y Comercialización e Investigación de Mercado

Selección de socios en las Empresas Virtuales Dinámicas

En el presente documento se describen los aspectos más importantes asociados a la aplicación software DVEBreeder. Esta herramienta ha sido creada expresamente para facilitar el proceso de selección de socios en las Empresas Virtuales Dinámicas utilizando, para ello, dos tecnologías procedentes del ámbito de la Inteligencia Artificial, como son los Sistemas Multiagente y los Sistemas Expertos. En dicha aplicación el proceso de selección se realiza en base a un modelo que engloba y amplía las posibilidades de los distintos enfoques existentes en la literatura, y en el que se hace uso del reciente concepto de Entornos de Gestación.Departamento de Informátic

An agent-based framework for selection of partners in dynamic virtual enterprises

Advances in computer networking technology and open system standards have made practically feasible to create and manage virtual enterprises. A virtual enterprise, VE, is usually defined as a temporary alliance of enterprises that come together to share their skills, core competencies, and resources in order to better respond to business opportunities, and whose cooperation is supported by computer networks. The materialization of this paradigm, although enabled by recent advances in communication technologies, computer networks and logistics, requires an appropriate architectural framework and support tools. In this paper we propose an agent-based model of a dynamic VE to support the different selection processes that are used in selecting the partners for a dynamic VE, where the partners of a VE are represented by agents. Such a framework will form the basis for tools that provide automated support for creation, and operation, of dynamic virtual enterprises

La metodología de aprendizaje SACC1. Desarrollo práctico de Competencias Transversales y Digitales en los Egresados Universitarios a través de la metodología SACC

Los continuos cambios en la sociedad y en las exigencias de mercado, los avances en las TIC, el auge de las redes sociales, el acceso universal a la información,…, plantean nuevos retos y desafíos a las empresas. Sin embargo, la mayoría de las empresas considera que su personal carece de las competencias y habilidades necesarias para responder de forma eficiente. La Universidad, entre cuyos fines se encuentra el formar a profesionales capaces de desarrollar un correcto ejercicio profesional y social, debe dar respuesta a esta necesidad. Por ello, resulta imprescindible reorientar la labor docente hacia un modelo que promueva el binomio “conocimientos-competencias”, acorde con el cambio que demanda el mercado y que, además, viene impulsando el EEES. Con este fin nace la metodología que aquí se describe, caracterizada por combinar tres estilos de aprendizaje (autónomo, colaborativo y competitivo) con el uso de las nuevas tecnologías, a fin de conseguir que los alumnos trabajen competencias transversales y digitales tanto dentro como fuera del aula. Se trata de una metodología fácil de desarrollar y generalizar, y que está proporcionado muy buenos resultados ya que los alumnos la perciben como novedosa, dinámica y motivadora

Ti(III) Catalysts for CO2/Epoxide Copolymerization at Unusual Ambient Pressure Conditions

Titanium compounds in low oxidation states are highly reducing species and hence powerful tools for the functionalization of small molecules. However, their potential has not yet been fully realized because harnessing these highly reactive complexes for productive reactivity is generally challenging. Advancing this field, herein we provide a detailed route for the formation of titanium(III) orthophenylendiamido (PDA) species using [LiBHEt3] as a reducing agent. Initially, the corresponding lithium PDA compounds [Li2(ArPDA)(thf)3] (Ar = 2,4,6-trimethylphenyl (MesPDA), 2,6-diisopropylphenyl (iPrPDA)) are combined with [TiCl4(thf)2] to form the heterobimetallic complexes [{TiCl(ArPDA)}(?-ArPDA){Li(thf)n}] (n = 1, Ar = iPr 3 and n = 2, Ar = Mes 4). Compound 4 evolves to species [Ti(MesPDA)2] (6) via thermal treatment. In contrast, the transformation of 3 into [Ti(iPrPDA)2] (5) only occurs in the presence of [LiNMe2], through a lithium-assisted process, as revealed by density functional theory (DFT). Finally, the Ti(IV) compounds 3?6 react with [LiBHEt3] to give rise to the Ti(III) species [Li(thf)4][Ti(ArPDA)2] (Ar = iPr 8, Mes 9). These low-valent compounds in combination with [PPN]Cl (PPN = bis(triphenylphosphine)iminium) are proved to be highly selective catalysts for the copolymerization of CO2 and cyclohexene epoxide. Reactions occur at 1 bar pressure with activity/selectivity levels similar to Salen? Cr(III) compounds.Comunidad de MadridUniversidad de AlcaláPrograma Estímulo a la Investigación de Jóvenes Investigadore

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our studies demonstrate attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound shows single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocks P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identify AcAS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient to cure a malaria infection in humans. Toxicology studies in rats indicate a \u3e 30-fold safety margin in relation to the predicted human efficacious exposure. In conclusion, MMV693183 represents a promising candidate for further (pre)clinical development with a novel mode of action for treatment of malaria and blocking transmission

OSIRIS – The scientific camera system onboard Rosetta

The Optical, Spectroscopic, and Infrared Remote Imaging System OSIRIS is the scientific camera system onboard the Rosetta spacecraft (Figure 1). The advanced high performance imaging system will be pivotal for the success of the Rosetta mission. OSIRIS will detect 67P/Churyumov-Gerasimenko from a distance of more than 106 km, characterise the comet shape and volume, its rotational state and find a suitable landing spot for Philae, the Rosetta lander. OSIRIS will observe the nucleus, its activity and surroundings down to a scale of ~2 cm px−1. The observations will begin well before the onset of cometary activity and will extend over months until the comet reaches perihelion. During the rendezvous episode of the Rosetta mission, OSIRIS will provide key information about the nature of cometary nuclei and reveal the physics of cometary activity that leads to the gas and dust coma. OSIRIS comprises a high resolution Narrow Angle Camera (NAC) unit and a Wide Angle Camera (WAC) unit accompanied by three electronics boxes. The NAC is designed to obtain high resolution images of the surface of comet 7P/Churyumov-Gerasimenko through 12 discrete filters over the wavelength range 250–1000 nm at an angular resolution of 18.6 μrad px−1. The WAC is optimised to provide images of the near-nucleus environment in 14 discrete filters at an angular resolution of 101 μrad px−1. The two units use identical shutter, filter wheel, front door, and detector systems. They are operated by a common Data Processing Unit. The OSIRIS instrument has a total mass of 35 kg and is provided by institutes from six European countrie

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries